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Can Pomegranate Consumption Prevent Alzheimer Disease?

Alzheimer disease represents the most prevalent form of dementia, accounting for up to 60% of all cases of dementia. Although there are multifactorial contributions to the development of most types of dememtia, including Alzheimer disease, there is a considerable amount of evidence indicating a strong correlation between inflammatory processes in the brain (termed neuroinflammation) and the progression of Alzheimer disease as well as other neurodegenerative conditions. In the process of neuroinflammation, pro-inflammatory cytokines, reactive oxygen species (ROS) and reactive nitrogen species (RNS), and pro-inflammatory lipids (especially prostaglandin E2 (PGE2), function as key contributors to the development and maintenance of inflammatory responses. Within the brain, neuroinflammatory processes are mediated through the microglia (a type of glial cell) that are the resident immune macrophages in the CNS and are responsible for active immune defense in the brain.

The pomegranate is th…

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